Risk factors, clinical features and treatment of Behçet's disease uveitis

Z Zhong, G Su, P Yang - Progress in Retinal and Eye Research, 2023 - Elsevier
Behçet's disease is a systemic vasculitis frequently associated with intraocular inflammation.
Recent findings identified independent clinical clusters in Behçet's disease, each involving …

Adhesion molecule targeted therapy for non-infectious uveitis

YH Chen, S Lightman, M Eskandarpour… - International Journal of …, 2022 - mdpi.com
Non-infectious uveitis (NIU) is an inflammatory eye disease initiated via CD4+ T-cell
activation and transmigration, resulting in focal retinal tissue damage and visual acuity …

Genetics of vasculitis

FD Carmona, J Martín… - Current opinion in …, 2015 - journals.lww.com
The analysis of high-throughput genotyping and exome-sequencing data has produced a
considerable advance in the identification of consistent genetic risk factors in vasculitides …

[PDF][PDF] Behçet's syndrome: a critical digest of the 2013-2014 literature

G Hatemi, E Seyahi, I Fresko, R Talarico… - Clin Exp …, 2014 - researchgate.net
This review focuses on the recent research on the epidemiology, outcome measures,
immunopathogenesis, genetics, clinical manifestations and management of Behçet's …

Association of functional polymorphisms of KIR3DL1/DS1 with Behcet's disease

Á Castaño-Núñez, MA Montes-Cano… - Frontiers in …, 2019 - frontiersin.org
Behçet's disease (BD) is an immune-mediated vasculitis related to imbalances between the
innate and adaptive immune response. Infectious agents or environmental factors may …

A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing

X Liu, J Meng, X Liao, Y Liu, Q Zhou, Z Xu… - Cellular & Molecular …, 2023 - nature.com
Abstract Vogt–Koyanagi–Harada (VKH) disease is a leading cause of blindness in young
and middle-aged people. However, the etiology of VKH disease remains unclear. Here, we …

Molecular functionality of CYP2C9 polymorphisms and their influence on drug therapy

YB Jarrar, SJ Lee - Drug metabolism and drug interactions, 2014 - degruyter.com
Abstract CYP2C9 metabolizes approximately 20% of clinically used drugs, including the
narrow therapeutic window drugs warfarin and phenytoin. More than 16,000 variants have …

A comprehensive overview on the genetics of Behcet's disease

M Mahmoudi, S Aslani, A Meguro… - International Reviews …, 2022 - Taylor & Francis
Behçet's disease (BD) is a systemic and inflammatory disease, characterized mainly by
recurrent oral and genital ulcers, eye involvement, and skin lesions. Although the exact …

Association of killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands with susceptibility to Behçet's‎ disease

H Mohammad-Ebrahim… - Scandinavian journal …, 2018 - Taylor & Francis
Objectives: Behçet's disease (BD) is a systemic inflammatory disorder with remissions and
exacerbations. It is thought that defects in the natural killer (NK) cell repertoire may be …

Ocular toxoplasmosis: susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands

CM Ayo, FB Frederico, RC Siqueira… - Scientific reports, 2016 - nature.com
The objective of this study was to investigate the influence of the genes encoding the KIR
receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 …