Kisspeptins and reproduction: physiological roles and regulatory mechanisms

L Pinilla, E Aguilar, C Dieguez, RP Millar… - Physiological …, 2012 - journals.physiology.org
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Neuroendocrinology of reproduction in teleost fish

Y Zohar, JA Muñoz-Cueto, A Elizur, O Kah - General and comparative …, 2010 - Elsevier
This review aims at synthesizing the most relevant information regarding the
neuroendocrine circuits controlling reproduction, mainly gonadotropin release, in teleost …

Kisspeptin signaling in the brain

AE Oakley, DK Clifton, RA Steiner - Endocrine reviews, 2009 - academic.oup.com
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

Melatonin: a multitasking molecule

RJ Reiter, DX Tan, L Fuentes-Broto - Progress in brain research, 2010 - Elsevier
Abstract Melatonin (N-acetyl-5-methoxytryptamine) has revealed itself as an ubiquitously
distributed and functionally diverse molecule. The mechanisms that control its synthesis …

Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B

RL Goodman, MN Lehman, JT Smith, LM Coolen… - …, 2007 - academic.oup.com
Kisspeptin is a potent stimulator of GnRH secretion that has been implicated in the feedback
actions of ovarian steroids. In ewes, the majority of hypothalamic kisspeptin neurons are …

Kisspeptin–GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge

J Clarkson, XA de Tassigny, AS Moreno… - Journal of …, 2008 - Soc Neuroscience
Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in
the neural control of fertility in animal models and humans. The gonadotropin-releasing …

Current knowledge on the photoneuroendocrine regulation of reproduction in temperate fish species

H Migaud, A Davie, JF Taylor - Journal of fish biology, 2010 - Wiley Online Library
Seasonality is an important adaptive trait in temperate fish species as it entrains or regulates
most physiological events such as reproductive cycle, growth profile, locomotor activity and …

Kisspeptin/GPR54 system: what do we know about its role in human reproduction?

CM Trevisan, E Montagna, R De Oliveira… - Cellular Physiology and …, 2018 - karger.com
Kisspeptin is involved in the control of human reproduction bridging the gap between the
sex steroid levels and feedback mechanisms that control the gonadotropin releasing …

Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation

AK Roseweir, AS Kauffman, JT Smith… - Journal of …, 2009 - Soc Neuroscience
Neurons that produce gonadotropin-releasing hormone (GnRH) are the final common
pathway by which the brain regulates reproduction. GnRH neurons are regulated by an …

KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season

JT Smith, CM Clay, A Caraty, IJ Clarke - Endocrinology, 2007 - academic.oup.com
The KiSS-1 gene encodes a family of peptides called kisspeptins, which are endogenous
ligands for the G protein-coupled receptor GPR54. Kisspeptin function appears to be critical …