The central goal of regenerative medicine is to replace damaged or diseased tissue with
cells that integrate and function optimally. The capacity of pluripotent stem cells to produce …

Despite the significant contributions of immunocompetent mouse models to the development
and assessment of cancer immunotherapies, they inadequately represent the genetic and …

Rationale: The in vivo dynamics of CAR-T cells remain incompletely understood. Novel
methods are urgently needed to longitudinally monitor transferred cells non-invasively for …

Periodontitis is an oral inflammatory disease in which the polymicrobial synergy and
dysbiosis of the subgingival microbiota trigger a deregulated host immune response, that …

Immunocompromised mouse strains expressing human transgenes are being increasingly
used in biomedical research. The genetic modifications in these mice cause various cellular …

The early detection and management of oral premalignant lesions (OPMDs) improve their
outcomes. Animal models that mimic histological and biological processes of human oral …

The humanized mouse (HM) has emerged as a valuable animal model in cancer research.
Engrafted with components of a human immune system and subsequently implanted with …

Despite the recent impressive clinical success of immunotherapy against melanoma,
development of primary and adaptive resistance against immune checkpoint inhibitors …

Objectives Humanised mice have emerged as valuable models for pre‐clinical testing of the
safety and efficacy of immunotherapies. Given the variety of models available, selection of …

Humanized mouse models have been widely used in virology, immunology, and oncology in
the last decade. With advances in the generation of knockout mouse strains, it is now …