Cancer cells are characterized by a metabolic shift in cellular energy production,
orchestrated by the transcription factor HIF-1α, from mitochondrial oxidative phosphorylation …

Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …

Glioblastoma (GBM) as the most common primary malignant brain tumor exhibits a high
incidence and degree of malignancy as well as poor prognosis. Due to the existence of …

Abnormal pH is a common feature of malignant tumors and has been associated clinically
with suboptimal outcomes. Amide proton transfer magnetic resonance imaging (APT MRI) …

Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo
metabolites changes or characterizing the tumor microenvironment, non-invasive imaging …

Water cycling across the membrane transporters is considered a hallmark of cellular
metabolism and it could be of high diagnostic relevance in the characterization of tumors …

Malignant glioma represents a fatal disease with a poor prognosis and development of
resistance mechanisms against conventional therapeutic approaches. The distinct tumor …

The notion that invasive cancer is a product of somatic evolution is a well-established theory
that can be modelled mathematically and demonstrated empirically from therapeutic …

The concept of using paramagnetic metal ion complexes as chemical exchange saturation
transfer agents (paraCEST) for molecular imaging of various biological processes first …

Co (II) complexes of 1, 4, 7, 10-tetraazacyclododecane (CYCLEN) or 1, 4, 8, 11-
tetraazacyclotetradecane (CYCLAM) with 2-hydroxypropyl or carbamoylmethyl (amide) …