Controlling the biodistribution and clearance of nanomedicines
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs …
ability, efficacy and safety compared to conventional freely administered drugs …
[HTML][HTML] An Overview of Nanotherapeutic Drug Delivery Options for the Management of Glioblastoma
WH Pentz, VJ Pizzuti, ME Halbert, TJ Plute… - Journal of …, 2023 - mdpi.com
Glioblastoma is the most common primary, malignant brain tumor that remains uniformly
lethal in nearly all cases as a result of extreme cellular heterogeneity, treatment resistance …
lethal in nearly all cases as a result of extreme cellular heterogeneity, treatment resistance …
[HTML][HTML] Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain
Focused ultrasound and microbubbles can non-invasively and locally deliver therapeutics
and imaging agents across the blood–brain barrier. Uniform treatment and minimal adverse …
and imaging agents across the blood–brain barrier. Uniform treatment and minimal adverse …
[HTML][HTML] Effects of whole-brain radiation therapy on the blood–brain barrier in immunocompetent and immunocompromised mouse models
Background Approximately 20% of all cancer patients will develop brain metastases in their
lifespan. The standard of care for patients with multiple brain metastases is whole-brain …
lifespan. The standard of care for patients with multiple brain metastases is whole-brain …
[HTML][HTML] Blood-tumor barrier opening by MRI-guided transcranial focused ultrasound in a preclinical breast cancer brain metastasis model improves efficacy of …
TA Arsiwala, KE Blethen, CP Wolford… - Frontiers in …, 2023 - frontiersin.org
Patients with metastatic breast cancer have high and continually increasing rates of brain
metastases. During the course of the disease, brain metastases can occur in up to 30% of …
metastases. During the course of the disease, brain metastases can occur in up to 30% of …
[HTML][HTML] Advances in focused ultrasound for the treatment of brain tumors
R Rao, A Patel, K Hanchate, E Robinson, A Edwards… - Tomography, 2023 - mdpi.com
Employing the full arsenal of therapeutics to treat brain tumors is limited by the relative
impermeability of the blood–brain and blood–tumor barriers. In physiologic states, the blood …
impermeability of the blood–brain and blood–tumor barriers. In physiologic states, the blood …
Consensus Review on Strategies to Improve Delivery Across the BBB Including Focused Ultrasound
K Piper, JI Kumar, J Domino, C Tuchek… - Neuro …, 2024 - academic.oup.com
Drug delivery to the central nervous system (CNS) has been a major challenge for CNS
tumors due to the impermeability of the blood brain barrier (BBB). There have been a …
tumors due to the impermeability of the blood brain barrier (BBB). There have been a …
[PDF][PDF] by utilizing natural transport mechanisms or disrupting the BBB.-New technologies have emerged as methods to temporarily disrupt the BBB and potentially …
MA Vogelbaum - 2024 - brainlife.org
Drug delivery to the central nervous system (CNS) has been a major challenge for CNS
tumors due to the impermeability of the blood brain barrier (BBB). There have been a …
tumors due to the impermeability of the blood brain barrier (BBB). There have been a …
[PDF][PDF] Single exposure to low-intensity focused ultrasound causes biphasic opening of the blood-brain barrier on the sonicated and contralateral treated regions.
TA Arsiwala, KE Blethen… - … modulation of the …, 2022 - researchrepository.wvu.edu
One of the fundamental functions of the blood-brain barrier (BBB) is to regulate the
movement of essential metabolites within the central nervous system (CNS)(1). The BBB is …
movement of essential metabolites within the central nervous system (CNS)(1). The BBB is …