CCR6 as a potential target for therapeutic antibodies for the treatment of inflammatory diseases
S Gómez-Melero, J Caballero-Villarraso - Antibodies, 2023 - mdpi.com
The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a
wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling …
wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling …
Methods for Engineering Binders to Multi-Pass Membrane Proteins
B Thomas, K Chockalingam, Z Chen - Bioengineering, 2023 - mdpi.com
Numerous potential drug targets, including G-protein-coupled receptors and ion channel
proteins, reside on the cell surface as multi-pass membrane proteins. Unfortunately, despite …
proteins, reside on the cell surface as multi-pass membrane proteins. Unfortunately, despite …
Identification of the Binding Epitope of an Anti-Mouse CCR6 Monoclonal Antibody (C6Mab-13) Using 1× Alanine Scanning
T Tanaka, M Tawara, H Suzuki, MK Kaneko, Y Kato - Antibodies, 2023 - mdpi.com
CC chemokine receptor 6 (CCR6) is one of the members of the G-protein-coupled receptor
(GPCR) family that is upregulated in many immune-related cells, such as B lymphocytes …
(GPCR) family that is upregulated in many immune-related cells, such as B lymphocytes …
[HTML][HTML] Progress of CCL20-CCR6 in the airways: a promising new therapeutic target
YJ Li, WL Geng, CC Li, JH Wu, F Gao… - Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
The chemokine CCL20, a small cytokine that belongs to the C–C chemokine family, interacts
with its homologous receptor CCR6, which is expressed on wide range of cell types …
with its homologous receptor CCR6, which is expressed on wide range of cell types …
Development of a high-throughput calcium mobilization assay for CCR6 receptor coupled to hydrolase activity readout
S Gómez-Melero, FI García-Maceira, T García-Maceira… - Biomedicines, 2022 - mdpi.com
CCR6 is a chemokine receptor highly implicated in inflammatory diseases and could be a
potential therapeutic target; however, no therapeutic agents targeting CCR6 have …
potential therapeutic target; however, no therapeutic agents targeting CCR6 have …
β-抑制蛋白1 在炎症反应调控中作用的研究进展
衣文婧， 范宜璇， 仇佳泰， 付晓燕… - 上海交通大学学报(医学 …, 2024 - xuebao.shsmu.edu.cn
炎症反应是机体应对感染或损伤等刺激时产生的系统性响应过程, 与多种疾病的发生机制密切
相关, 并在疾病进展与转归过程中起着重要作用. 正常情况下, 炎症反应能够在机体受损不严重时 …
相关, 并在疾病进展与转归过程中起着重要作用. 正常情况下, 炎症反应能够在机体受损不严重时 …
Establishment of a Novel Anti-Human CCR6 Monoclonal Antibody C6Mab-19 with the High Binding Affinity in Flow Cytometry
T Tanaka, K Kitamura, H Suzuki… - Monoclonal Antibodies …, 2023 - liebertpub.com
CC chemokine receptor 6 (CCR6) is a member of the G-protein-coupled receptor family that
is highly expressed in B lymphocytes, effector and memory T cells, regulatory T cells, and …
is highly expressed in B lymphocytes, effector and memory T cells, regulatory T cells, and …
[PDF][PDF] Identification of the Binding Epitope of an Anti-Mouse CCR6 Monoclonal Antibody (C6Mab-13) Using 1× Alanine Scanning. Antibodies 2023, 12, 32
T Tanaka, M Tawara, H Suzuki, MK Kaneko, Y Kato - 2023 - academia.edu
CC chemokine receptor 6 (CCR6) is one of the members of the G-protein-coupled receptor
(GPCR) family that is upregulated in many immune-related cells, such as B lymphocytes …
(GPCR) family that is upregulated in many immune-related cells, such as B lymphocytes …
Research progress in the role of β-arrestin 1 in the regulation of inflammatory response
YI Wenjing, FAN Yixuan, QIU Jiatai… - Journal of Shanghai …, 2024 - xuebao.shsmu.edu.cn
The inflammatory response is a systemic process produced by the body in response to
stimulation such as infection or injury. The inflammatory response is closely related to the …
stimulation such as infection or injury. The inflammatory response is closely related to the …