Plants have evolved to synthesize a variety of noxious compounds to cope with unfavorable
circumstances, among which a large group of toxic proteins that play a critical role in plant …

Immunotoxins (ITs) are attractive anticancer modalities aimed at cancer-specific delivery of
highly potent cytotoxic protein toxins. An IT consists of a targeting domain (an antibody …

Synonymous codons encode the same amino acid, but differ in other biophysical properties.
The evolutionary selection of codons whose properties are optimal for a cell generates the …

Ribosome-inactivating proteins (RIPs) are EC3. 2.32. 22 N-glycosidases that recognize a
universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single …

Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as
saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and …

Simple Summary Discovered more than three decades ago, the urokinase-type
plasminogen activator receptor (uPAR) has now firmly established itself as a versatile …

Background Structural and biochemical studies of mammalian membrane proteins remain
hampered by inefficient production of pure protein. We explored codon optimization based …

The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …

Plant ribosome-inactivating protein (RIP) toxins are EC3. 2.2. 22 N-glycosidases, found
among most plant species encoded as small gene families, distributed in several tissues …

Plant Ribosome-inactivating proteins (RIPs) including the type I RIP Saporin have been
used for the construction of Immunotoxins (ITxs) obtained via chemical conjugation of the …