Preclinical and clinical development of noncoding RNA therapeutics for cardiovascular disease
RNA modulation has become a promising therapeutic approach for the treatment of several
types of disease. The emerging field of noncoding RNA-based therapies has now come to …
types of disease. The emerging field of noncoding RNA-based therapies has now come to …
[HTML][HTML] Passive myocardial mechanical properties: meaning, measurement, models
R Emig, CM Zgierski-Johnston, V Timmermann… - Biophysical …, 2021 - Springer
Passive mechanical tissue properties are major determinants of myocardial contraction and
relaxation and, thus, shape cardiac function. Tightly regulated, dynamically adapting …
relaxation and, thus, shape cardiac function. Tightly regulated, dynamically adapting …
Microtubules increase diastolic stiffness in failing human cardiomyocytes and myocardium
Background: Diastolic dysfunction is a prevalent and therapeutically intractable feature of
heart failure (HF). Increasing ventricular compliance can improve diastolic performance, but …
heart failure (HF). Increasing ventricular compliance can improve diastolic performance, but …
[HTML][HTML] Mechanical homeostasis in tissue equivalents: a review
There is substantial evidence that growth and remodeling of load bearing soft biological
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …
[HTML][HTML] Pathogenic mechanisms of hypertrophic cardiomyopathy beyond sarcomere dysfunction
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder,
affecting 1 in 500 people in the general population. Although characterized by asymmetric …
affecting 1 in 500 people in the general population. Although characterized by asymmetric …
[HTML][HTML] Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes
The vast potential of human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-
CMs) in preclinical models of cardiac pathologies, precision medicine, and drug screening …
CMs) in preclinical models of cardiac pathologies, precision medicine, and drug screening …
[HTML][HTML] Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction
KD Dwyer, KLK Coulombe - Bioactive Materials, 2021 - Elsevier
The mechanical environment and anisotropic structure of the heart modulate cardiac
function at the cellular, tissue and organ levels. During myocardial infarction (MI) and …
function at the cellular, tissue and organ levels. During myocardial infarction (MI) and …
Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation
LR Sewanan, J Park, MJ Rynkiewicz… - Journal of General …, 2021 - rupress.org
Hypertrophic cardiomyopathy (HCM) is an inherited disorder caused primarily by mutations
to thick and thinfilament proteins. Although thin filament mutations are less prevalent than …
to thick and thinfilament proteins. Although thin filament mutations are less prevalent than …
[HTML][HTML] Stochastic non-enzymatic modification of long-lived macromolecules-A missing hallmark of aging
A Fedintsev, A Moskalev - Ageing research reviews, 2020 - Elsevier
Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM)
proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging …
proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging …
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
C Rixon, K Andreassen, X Shen… - ESC Heart …, 2023 - Wiley Online Library
Aims Familial hypertrophic cardiomyopathy (HCM) is the most common form of inherited
cardiac disease. It is characterized by myocardial hypertrophy and diastolic dysfunction, and …
cardiac disease. It is characterized by myocardial hypertrophy and diastolic dysfunction, and …