RNA modulation has become a promising therapeutic approach for the treatment of several
types of disease. The emerging field of noncoding RNA-based therapies has now come to …

Passive mechanical tissue properties are major determinants of myocardial contraction and
relaxation and, thus, shape cardiac function. Tightly regulated, dynamically adapting …

Background: Diastolic dysfunction is a prevalent and therapeutically intractable feature of
heart failure (HF). Increasing ventricular compliance can improve diastolic performance, but …

There is substantial evidence that growth and remodeling of load bearing soft biological
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder,
affecting 1 in 500 people in the general population. Although characterized by asymmetric …

The vast potential of human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-
CMs) in preclinical models of cardiac pathologies, precision medicine, and drug screening …

The mechanical environment and anisotropic structure of the heart modulate cardiac
function at the cellular, tissue and organ levels. During myocardial infarction (MI) and …

Hypertrophic cardiomyopathy (HCM) is an inherited disorder caused primarily by mutations
to thick and thinfilament proteins. Although thin filament mutations are less prevalent than …

Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM)
proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging …

Aims Familial hypertrophic cardiomyopathy (HCM) is the most common form of inherited
cardiac disease. It is characterized by myocardial hypertrophy and diastolic dysfunction, and …