Chronic activation of the renin‐angiotensin‐aldosterone system (RAAS) promotes and
perpetuates the syndromes of congestive heart failure, systemic hypertension, and chronic …

Inflammation, a process intimately linked to renal disease, can be defined as a complex
network of interactions between renal parenchymal cells and resident immune cells, such as …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

In patients with renal diseases characterized by proteinuria, the initial insult to the kidney is
usually followed by a progressive decline in the glomerular filtration rate. This decline has …

First published August 9, 2001; 10.1152/ajprenal. 00050.2001.—Acute episodes of severe
renal ischemia result in acute renal failure (ARF). These episodes are followed by a …

A growing body of evidence supports the notion that angiotensin II (Ang II), the central
product of the renin-angiotensin system, may play a central role not only in the etiology of …

Progression of fibrosis involves interstitial hypercellularity, matrix accumulation, and atrophy
of epithelial structures, resulting in loss of normal function and ultimately organ failure. There …

The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of
glomerular injury? Although the glomerulus, particularly the mesangium, has been the focus …

Background Long-term outcomes after acute kidney injury remain poorly defined. We
determined the association between the magnitude of creatinine increase after cardiac …

Angiotensin (Ang) II, the main peptide of the renin angiotensin system (RAS), is a renal
growth factor, inducing hyperplasia/hypertrophy depending on the cell type. This vasoactive …