Our understanding of the ubiquitin code has greatly evolved from conventional E1, E2 and
E3 enzymes that modify Lys residues on specific substrates with a single type of ubiquitin …

Protein ubiquitination is one of the most powerful posttranslational modifications of proteins,
as it regulates a plethora of cellular processes in distinct manners. Simple …

Ubiquitin acts as a versatile cellular signal that controls a wide range of biological processes
including protein degradation, DNA repair, endocytosis, autophagy, transcription, immunity …

Background: Pathological cardiac hypertrophy can lead to heart failure and is one of the
leading causes of death globally. Understanding the molecular mechanism of pathological …

Post-translational modifications (PTMs) occur in almost all proteins and play an important
role in numerous biological processes by significantly affecting proteins' structure and …

Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular
processes in eukaryotes through highly specific modification of numerous cellular proteins …

Post-translational modifications such as ubiquitination play important regulatory roles in
several biological processes in eukaryotes. This process could be reversed by …

Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes.
Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of …

Abstract Interleukin 17 (IL-17) is important in infection and autoimmunity; how it signals
remains poorly understood. In this study, we identified the ubiquitin-specific protease USP25 …

Understanding the normal function of the Huntingtin (HTT) protein is of significance in the
design and implementation of therapeutic strategies for Huntington's disease (HD) …