Ischemia and reperfusion–elicited tissue injury contributes to morbidity and mortality in a
wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney …

Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney
transplantation and influences short term as well as long-term graft outcome. Clinically …

During their development, B and T cells with self-reactive antigen receptors are generally
deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 …

Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century
ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen …

The existence of IgM has been known for more than a century, but its importance in immunity
and autoimmunity continues to emerge. Studies of mice deficient in secreted IgM have …

Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-
tuning of the recognition and response to foreign threats. However, in health there are some …

Natural IgM antibodies secreted in the absence of antigenic challenge are important
contributors to antimicrobial immunity and tissue homeostasis. Early studies identified BM …

Most natural IgM antibodies are encoded by germline Ig sequences and are produced in
large quantities by both mice and humans in the absence of intentional immunization …

Despite the success of reperfusion therapy in significantly reducing the extent of infarct
expansion after stroke, the effect of revascularization on poststroke neuroinflammation and …

Lung ischemia reperfusion injury (LIRI) is a pathologic process occurring when oxygen
supply to the lung has been compromised followed by a period of reperfusion. The …