Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Z Luo, M Tian, G Yang, Q Tan, Y Chen, G Li… - Signal transduction and …, 2022 - nature.com
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

[HTML][HTML] Microbiome and cancer

N Cullin, CA Antunes, R Straussman… - Cancer Cell, 2021 - cell.com
The human microbiome constitutes a complex multikingdom community that symbiotically
interacts with the host across multiple body sites. Host-microbiome interactions impact …

Upper gastrointestinal bleeding: etiologies and management

AK Kamboj, P Hoversten, CL Leggett - Mayo Clinic Proceedings, 2019 - Elsevier
Upper gastrointestinal bleeding is a medical condition routinely encountered in clinical
practice. Overt upper gastrointestinal bleeding usually presents as melena or hematemesis …

Eradication of Helicobacter pylori and Gastric Cancer: A Controversial Relationship

M Piscione, M Mazzone, MC Di Marcantonio… - Frontiers in …, 2021 - frontiersin.org
Worldwide, gastric cancer (GC) represents the fifth cancer for incidence, and the third as
cause of death in developed countries. Indeed, it resulted in more than 780,000 deaths in …

Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets

P Roszczenko-Jasińska, MI Wojtyś… - Applied Microbiology …, 2020 - Springer
Helicobacter pylori, a member of Epsilonproteobacteria, is a Gram-negative microaerophilic
bacterium that colonizes gastric mucosa of about 50% of the human population. Although …

Antibiotic resistance in Helicobacter pylori

C Alba, A Blanco, T Alarcón - Current opinion in infectious …, 2017 - journals.lww.com
Metronidazole and clarithromycin resistance rates are alarming although they vary among
populations. Tetracycline and amoxicillin-resistance are very low in most countries. H. pylori …

Influence of Helicobacter pylori virulence factors CagA and VacA on pathogenesis of gastrointestinal disorders

S Nejati, A Karkhah, H Darvish, M Validi… - Microbial …, 2018 - Elsevier
Helicobacter Pylori (H. pylori) is a gram-negative bacteria infecting numerous people all
over the world. It has been established that H. pylori play an important role in pathogenesis …

Dysbiosis from a microbial and host perspective relative to oral health and disease

C Cugini, N Ramasubbu, VK Tsiagbe… - Frontiers in …, 2021 - frontiersin.org
The significance of microbiology and immunology with regard to caries and periodontal
disease gained substantial clinical or research consideration in the mid 1960's. This …

Development of composite, reinforced, highly drug-loaded pharmaceutical printlets manufactured by selective laser sintering—in search of relevant excipients for …

P Kulinowski, P Malczewski, M Łaszcz, E Baran… - Materials, 2022 - mdpi.com
3D printing by selective laser sintering (SLS) of high-dose drug delivery systems using pure
brittle crystalline active pharmaceutical ingredients (API) is possible but impractical …

Research progress on gut microbiota in patients with gastric cancer, esophageal cancer, and small intestine cancer

C Chen, L Chen, L Lin, D Jin, Y Du, J Lyu - Applied microbiology and …, 2021 - Springer
The pathogenesis of gut microbiota in humans can be indicated due to the wide application
of techniques, such as 16S rRNA sequencing. Presently, several studies have found a …