Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

Microbial natural products have provided an important source of therapeutic leads and
motivated research and innovation in diverse scientific disciplines. In recent years, it has …

Streptomyces is taken as an important resource for producing the most abundant antibiotics
and other bio-active natural products, which have been widely used in pharmaceutical and …

Actinomycetes are the main sources of antibiotics. The onset and level of production of each
antibiotic is subject to complex control by multi-level regulators. These regulators exert their …

Two regulatory genes, jadR2 and jadR3, in the jadomycin (jad) biosynthetic gene cluster of
S treptomyces venezuelae encode homologues of γ‐butyrolactone receptor. JadR2 was …

Mureidomycins (MRDs), a group of unique uridyl-peptide antibiotics, exhibit antibacterial
activity against the highly refractory pathogen Pseudomonas aeruginosa. Our previous study …

Jadomycin production is under complex regulation in S treptomyces venezuelae. Here,
another cluster‐situated regulator, JadR*, was shown to negatively regulate jadomycin …

The numerous secondary metabolites in Streptomyces spp. are crucial for various
applications. For example, cephamycin C is used as an antibiotic, and avermectin is used as …

Abstract Validamycin A (VAL-A) is a C 7 N aminocyclitol antibiotic produced by
Streptomyces hygroscopicus var. jinggangensis 5008, which has been widely used as …

Gougerotin is a peptidyl nucleoside antibiotic. It functions as a specific inhibitor of protein
synthesis by binding ribosomal peptidyl transferase and exhibits a broad spectrum of …