Natural bioactive compounds-doxorubicin combinations targeting topoisomerase II-alpha: Anticancer efficacy and safety

A Elfadadny, RF Ragab, R Hamada… - Toxicology and Applied …, 2023 - Elsevier
Cancer is one of the leading causes of death worldwide, so pursuing effective and safe
therapeutics for cancer is a key research objective nowadays. Doxorubicin (DOX) is one of …

Design and development of novel nutraceuticals: Current trends and methodologies

T Tsiaka, E Kritsi, K Tsiantas, P Christodoulou… - Nutraceuticals, 2022 - mdpi.com
Over the past few years, nutraceuticals have gained substantial attention due to the health-
promoting and disease-preventing functions behind their nutritional value. The global …

Formulation, Optimization, and Evaluation of Moringa oleifera Leaf Polyphenol-Loaded Phytosome Delivery System against Breast Cancer Cell Lines

J Wanjiru, J Gathirwa, E Sauli, HS Swai - Molecules, 2022 - mdpi.com
Moringa oleifera leaf polyphenols (Mopp) were encapsulated with phytosomes to enhance
their efficacy on 4T1 cancer cell lines. The Mopp were extracted via microwave-assisted …

Rutin attenuates D-galactose-induced oxidative stress in rats' brain and liver: molecular docking and experimental approaches

SM Saafan, SA Mohamed, AE Noreldin… - Food & Function, 2023 - pubs.rsc.org
Oxidative stress results from the imbalance between reactive oxygen species (ROS)
production and antioxidant defence and is primarily involved in aging. The current study …

Carbon nanofibers versus silver nanoparticles: Time-dependent cytotoxicity, proliferation, and gene expression

B Salesa, M Assis, J Andrés, Á Serrano-Aroca - Biomedicines, 2021 - mdpi.com
Carbon nanofibers (CNFs) are one-dimensional nanomaterials with excellent physical and
broad-spectrum antimicrobial properties characterized by a low risk of antimicrobial …

The emerging potential of parthenolide nanoformulations in tumor therapy

T An, H Yin, Y Lu, F Liu - Drug Design, Development and Therapy, 2023 - Taylor & Francis
Plant-derived sesquiterpene lactones are promising natural sources for the discovery of anti-
cancer drugs. As an extensively studied sesquiterpene lactone, the tumor suppression effect …

[HTML][HTML] SPME and solvent-based GC–MS metabolite profiling of Egyptian marketed Saussurea costus (Falc.) Lipsch. concerning its anticancer activity

E Mohsen, AH El-Far, K Godugu, F Elsayed… - Phytomedicine Plus, 2022 - Elsevier
Abstract Background Saussurea costus Falc with synonymous Aucklandia costus, S. lappa,
and A. lappa, is an ancient perennial plant native to Himalayan region. Purpose S. costus …

Green synthesis of Brassica carinata microgreen silver nanoparticles, characterization, safety assessment, and antimicrobial activities

D Somda, JL Bargul, JM Wesonga, SW Wachira - Scientific Reports, 2024 - nature.com
Nanotechnology has been a central focus of scientific investigation over the past decades
owing to its versatile applications. The synthesis of silver nanoparticles (AgNPs) through …

Phytosesquiterpene lactones deregulate mitochondrial activity and phenotypes associated with triple-negative breast cancer metastasis

YT Cheng, DM Chang, YC Tung, PW Hsiao… - Phytomedicine, 2024 - Elsevier
Background Triple-negative breast cancer (TNBC) recurrence and metastasis are the major
causes of failure in TNBC therapy. The difficulties in treating TNBCs may be because of …

Inhibiting AGS Cancer Cell Proliferation through the Combined Application of Aucklandiae Radix and Hyperthermia: Investigating the Roles of Heat Shock Proteins …

CR Ahn, IJ Ha, JE Kim, KS Ahn, J Park, SH Baek - Antioxidants, 2024 - mdpi.com
Cancer is a major global health concern. To address this, the combination of traditional
medicine and newly appreciated therapeutic modalities has been gaining considerable …