Gliomas are the most malignant and aggressive form of brain tumors, and account for the
majority of brain cancer related deaths. Malignant gliomas, including glioblastoma are …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often
exhibit mesenchymal, stem-like phenotypes that could explain their resistance to therapy …

Aberrant expression of transcription factor AP-2α has been functionally associated with
various cancers, but its clinical significance and molecular mechanisms in human glioma …

Glioblastoma multiforme (GBM) is the most common primary malignancy in the brain and
confers a uniformly poor prognosis. Despite decades of research on the topic, limited …

Glioblastoma (GBM), a WHO-defined Grade IV astrocytoma, is the most common and
aggressive CNS malignancy. Despite current treatment modalities, the survival time remains …

Octamer-binding transcription factor 4 (Oct4), a homeodomain transcription factor, is well
established as a master factor controlling the self-renewal and pluripotency of pluripotent …

Extracellular free amino acids contribute to the interaction between a tumor and its
microenvironment through effects on cellular metabolism and malignant behavior. System xc …

Notch receptors play an essential role in the regulation of central cellular processes during
embryonic and postnatal development. The mammalian genome encodes for four Notch …

Gliomas are the most common primary tumour in the central nervous system in adults. The
pathological hallmark of gliomas is their propensity for extensive infiltration into the …