Genetic contributions to autism spectrum disorder
A Havdahl, M Niarchou, A Starnawska… - Psychological …, 2021 - cambridge.org
Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …
conditions characterized by early childhood-onset impairments in communication and social …
The role of DNA methylation in cancer
R Lakshminarasimhan, G Liang - DNA Methyltransferases-Role and …, 2016 - Springer
The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …
changes. With the advent of next-generation sequencing and large-scale multinational …
[HTML][HTML] Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
Background DNA methylation is one of the main epigenetic mechanisms for the regulation of
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development
Y Yang, X Fan, J Yan, M Chen, M Zhu… - Nucleic acids …, 2021 - academic.oup.com
DNA methylation is important for the epigenetic regulation of gene expression and plays a
critical role in mammalian development. However, the dynamic regulation of genome-wide …
critical role in mammalian development. However, the dynamic regulation of genome-wide …
Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation
X-chromosome inactivation (XCI) achieves dosage compensation between males and
females through the silencing of the majority of genes on one of the female X chromosomes …
females through the silencing of the majority of genes on one of the female X chromosomes …
Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation
Advances in sequencing technology allow researchers to map genome-wide changes in
DNA methylation in development and disease. However, there is a lack of experimental …
DNA methylation in development and disease. However, there is a lack of experimental …
Prenatal maternal stress predicts methylation of genes regulating the hypothalamic–pituitary–adrenocortical system in mothers and newborns in the Democratic …
Exposure to stress early in life permanently shapes activity of the hypothalamic–pituitary–
adrenocortical (HPA) axis and the brain. Prenatally, glucocorticoids pass through the …
adrenocortical (HPA) axis and the brain. Prenatally, glucocorticoids pass through the …
[HTML][HTML] DNA methylation markers for kidney function and progression of diabetic kidney disease
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
Detection and accurate false discovery rate control of differentially methylated regions from whole genome bisulfite sequencing
With recent advances in sequencing technology, it is now feasible to measure DNA
methylation at tens of millions of sites across the entire genome. In most applications …
methylation at tens of millions of sites across the entire genome. In most applications …
The epigenetic landscape of transgenerational acclimation to ocean warming
Epigenetic inheritance is a potential mechanism by which the environment in one
generation can influence the performance of future generations. Rapid climate change …
generation can influence the performance of future generations. Rapid climate change …