Immunometabolic mechanisms of heart failure with preserved ejection fraction
GG Schiattarella, P Alcaide, G Condorelli… - Nature cardiovascular …, 2022 - nature.com
Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide,
already accounting for at least half of all cases of heart failure. As most patients with HFpEF …
already accounting for at least half of all cases of heart failure. As most patients with HFpEF …
Heterologous immunity: role in natural and vaccine-induced resistance to infections
B Agrawal - Frontiers in immunology, 2019 - frontiersin.org
The central paradigm of vaccination is to generate resistance to infection by a specific
pathogen when the vacinee is re-exposed to that pathogen. This paradigm is based on two …
pathogen when the vacinee is re-exposed to that pathogen. This paradigm is based on two …
[HTML][HTML] SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
T cell immunity is central for the control of viral infections. To characterize T cell immunity,
but also for the development of vaccines, identification of exact viral T cell epitopes is …
but also for the development of vaccines, identification of exact viral T cell epitopes is …
CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19
V Mallajosyula, C Ganjavi, S Chakraborty… - Science …, 2021 - science.org
A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …
Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination
Y Maringer, A Nelde, SM Schroeder… - Science …, 2022 - science.org
Several COVID-19 vaccines are approved to prevent severe disease outcome after SARS-
CoV-2 infection. Whereas induction and functionality of antiviral antibody response are …
CoV-2 infection. Whereas induction and functionality of antiviral antibody response are …
Functional characterization of CD4+ T cell receptors crossreactive for SARS-CoV-2 and endemic coronaviruses
AG Dykema, B Zhang, BA Woldemeskel… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND Recent studies have reported T cell immunity to the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) in unexposed donors, possibly due to …
respiratory syndrome coronavirus 2 (SARS-CoV-2) in unexposed donors, possibly due to …
Current challenges for unseen-epitope TCR interaction prediction and a new perspective derived from image classification
The prediction of epitope recognition by T-cell receptors (TCRs) has seen many
advancements in recent years, with several methods now available that can predict …
advancements in recent years, with several methods now available that can predict …
TCR-BERT: learning the grammar of T-cell receptors for flexible antigen-binding analyses
The T-cell receptor (TCR) allows T-cells to recognize and respond to antigens presented by
infected and diseased cells. However, due to TCRs' staggering diversity and the complex …
infected and diseased cells. However, due to TCRs' staggering diversity and the complex …
Checkpoint inhibitor immune-related adverse events: A focused review on autoantibodies and B cells as biomarkers, advancements and future possibilities
The use of immune checkpoint inhibitors (ICIs) has evolved rapidly with unprecedented
treatment benefits being obtained for cancer patients, including improved patient survival …
treatment benefits being obtained for cancer patients, including improved patient survival …
Contriving multi-epitope vaccine ensemble for monkeypox disease using an immunoinformatics approach
The current global outbreak of monkeypox (MPX) disease, caused by Monkeypox virus
(MPXV), has resulted in 16 thousand infection cases, five deaths, and has been declared a …
(MPXV), has resulted in 16 thousand infection cases, five deaths, and has been declared a …