Young-onset colorectal cancer
MCW Spaander, AG Zauber, S Syngal… - Nature reviews Disease …, 2023 - nature.com
In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …
BRCA mutations in ovarian and prostate cancer: bench to bedside
Simple Summary DNA damage is one of the hallmarks of cancer. Epithelial ovarian cancer
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …
ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma
N Concin, X Matias-Guiu, I Vergote, D Cibula… - International Journal of …, 2021 - ijgc.bmj.com
A European consensus conference on endometrial carcinoma was held in 2014 to produce
multi-disciplinary evidence-based guidelines on selected questions. Given the large body of …
multi-disciplinary evidence-based guidelines on selected questions. Given the large body of …
Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions
Genetic variation can predispose to disease both through (i) monogenic risk variants that
disrupt a physiologic pathway with large effect on disease and (ii) polygenic risk that …
disrupt a physiologic pathway with large effect on disease and (ii) polygenic risk that …
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
P Møller, TT Seppälä, I Bernstein, E Holinski-Feder… - Gut, 2018 - gut.bmj.com
Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now
survive both their first and subsequent cancers, resulting in a growing number of older …
survive both their first and subsequent cancers, resulting in a growing number of older …
Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and …
KJ Monahan, N Bradshaw, S Dolwani, B Desouza… - Gut, 2020 - gut.bmj.com
Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost
30% of the population in the UK have a family history of CRC. The quantification of an …
30% of the population in the UK have a family history of CRC. The quantification of an …
European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
TT Seppälä, A Latchford, I Negoi… - British Journal of …, 2021 - academic.oup.com
Background Lynch syndrome is the most common genetic predisposition for hereditary
cancer but remains underdiagnosed. Large prospective observational studies have recently …
cancer but remains underdiagnosed. Large prospective observational studies have recently …
Colorectal cancer in the young: epidemiology, prevention, management.
Colorectal cancer (CRC) incidence rates in the United States overall have declined since
the mid-1980s because of changing patterns in risk factors (eg, decreased smoking) and …
the mid-1980s because of changing patterns in risk factors (eg, decreased smoking) and …
Lynch syndrome–associated colorectal cancer
FA Sinicrope - New England Journal of Medicine, 2018 - Mass Medical Soc
Key Clinical Points Lynch Syndrome–Associated Colorectal Cancer The Lynch syndrome is
the most common inherited syndrome associated with colorectal cancer, accounting for 3 …
the most common inherited syndrome associated with colorectal cancer, accounting for 3 …