Organoboron reagents represent a unique class of compounds because of their utility in
modern synthetic organic chemistry, often affording unprecedented reactivity. The …

The C–F bond is the strongest single bond in organic compounds. It is the most challenging
task to study the activation of the C–F bond in organic synthesis. Trifluoromethyl-containing …

Carbon dioxide (CO2) is an important C1 source for the generation of important carboxylic
acids and derivatives. Stoichiometric and catalytic carboxylation of nucleophiles, including …

Partially fluorinated alkanes, arenes, and alkenes can be transformed by a variety of
transition metal and lanthanide systems. Although the C–H bond is weaker than the C–F …

Much progress has been made in the development of methods to both create compounds
that contain C− F bonds and to functionalize C− F bonds. As such, C− F bonds are becoming …

C–F bond activation has drawn a lot of attention in the past, and the case of C (sp3)–F bonds
is particularly interesting as those are the strongest single bonds carbon makes with any …

An effective Cu-catalyzed selective formal carboxylation of C–F bonds with an atmospheric
pressure of CO2 is reported. A variety of gem-difluoroalkenes, gem-difluorodienes, and α …

C–F bond activation is currently considered to be “a hot topic” in many different but
interconnected fields of research, due to its inherent inertness and unique properties. While …

Delivering metallomimetic reactivity from simple p-block compounds is highly desirable in
the search to replace expensive, scarce precious metals by cheap and abundant elements …

The methyl-d3 group is a new isotopic functional group for medicine design. In this work, we
report an electrochemical deuteration approach for converting aromatic trifluoromethyl to …