Male fertility is closely related to the normal function of the hypothalamicpituitary-testicular
axis. The testis is an important male reproductive organ that secretes androgen and …

As the essential sexual hormone, estrogen and its receptor has been proved to participate in
the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor …

Context The effect of kaempferol, a regulator of oestrogen receptors, on atherosclerosis (AS)
and the underlying mechanism is elusive. Objective To explore the effect and mechanism of …

High risk-human papillomaviruses (HPVs) are known carcinogens. Numerous reports have
linked the steroid hormone estrogen, and the expression of estrogen receptors (ERs), to …

Research in preclinical models indicates that estrogens are neuroprotective and positively
impact cognitive aging. However, clinical data are equivocal as to the benefits of …

Estrogen receptor alpha (ERα) is a transcription factor activated by estrogenic hormones to
regulate gene expression in certain organs, including the brain. In the brain, estrogen …

Type 2 diabetes (T2D) is associated with a plethora of comorbidities, including osteoporosis,
which occurs due to an imbalance between bone resorption and formation. Numerous …

Acyl-CoA Synthetase long-chain family member 4 (ACSL4) is a member of acyl-CoA
synthetase protein long-chain family, which is associated with amino acid synthesis, lipid …

Due to potential health risks, current recommendations are that individuals who wish to use
hormone therapy to treat menopausal symptoms do so for the shortest period of time …

Estrogens have been implicated in the etiology of breast cancer for a long time. It has been
stated that long-term exposure to estrogens is associated with a higher incidence of breast …