The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Atrial natriuretic peptide (ANP) and brain (B-type) natriuretic peptide (BNP) are circulating
hormones of cardiac origin that play an important role in the regulation of intravascular blood …

Engineering functional human cardiac tissue that mimics the native adult morphological and
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …

Expression of sarcoplasmic reticulum (SR) Ca (2+)-ATPase was shown to be reduced in
failing human myocardium. The functional relevance of this finding, however, is not known …

Background We have demonstrated that brain natriuretic peptide (BNP) is a cardiac
hormone predominantly synthesized in and secreted from the ventricle. We have also …

Background Previous studies provide considerable evidence that excitation-contraction
coupling may be disturbed at the level of the sarcoplasmic reticulum (SR) in the failing …

BACKGROUND Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type
natriuretic peptide (CNP) are a family of structurally related peptides that participate in the …

Despite its importance for the regulation of heart function, little is known about the isoform
expression of the multifunctional Ca2+/calmodulin-dependent protein kinase (CaMKII) in …

In patients with heart failure, plasma levels of atrial natriuretic peptide (ANP), B-type
natriuretic peptide (BNP), and the N-terminal fragments of their prohormones (N-ANP and N …