Aβ-oligomers: A potential therapeutic target for Alzheimer's disease

S Ghosh, R Ali, S Verma - International Journal of Biological …, 2023 - Elsevier
The cascade of amyloid formation relates to multiple complex events at the molecular level.
Previous research has established amyloid plaque deposition as the leading cause of …

[PDF][PDF] Lo Sasso

G Bivona, CM Gambino - Int. J. Mol. Sci, 2023 - iris.unipa.it
Alzheimer's Disease (AD) is the most common cause of dementia, having a remarkable
social and healthcare burden worldwide. Amyloid β (Aβ) and protein Tau aggregates are …

[HTML][HTML] Microglial activation and priming in Alzheimer's disease: state of the art and future perspectives

G Bivona, M Iemmolo, L Agnello, B Lo Sasso… - International Journal of …, 2023 - mdpi.com
Alzheimer's Disease (AD) is the most common cause of dementia, having a remarkable
social and healthcare burden worldwide. Amyloid β (Aβ) and protein Tau aggregates are …

[HTML][HTML] Therapeutic strategies aimed at improving neuroplasticity in Alzheimer disease

MF Colavitta, FJ Barrantes - Pharmaceutics, 2023 - mdpi.com
Alzheimer disease (AD) is the most prevalent form of dementia among elderly people.
Owing to its varied and multicausal etiopathology, intervention strategies have been highly …

[HTML][HTML] CX3CL1 pathway as a molecular target for treatment strategies in Alzheimer's disease

G Bivona, M Iemmolo, G Ghersi - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is a scourge for patients, caregivers and healthcare professionals
due to the progressive character of the disease and the lack of effective treatments. AD is …

[HTML][HTML] Unveiling the molecular Footprint: Proteome-based biomarkers for Alzheimer's disease

M Jain, R Dhariwal, N Patil, S Ojha, R Tendulkar… - Proteomes, 2023 - mdpi.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
progressive cognitive decline and memory loss. Early and accurate diagnosis of AD is …

[HTML][HTML] Realization of amyloid-like aggregation as a common cause for pathogenesis in diseases

S Naskar, N Gour - Life, 2023 - mdpi.com
Amyloids were conventionally referred to as extracellular and intracellular accumulation of
Aβ42 peptide, which causes the formation of plaques and neurofibrillary tangles inside the …

Neuroprotective and anti‐inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies

E Azzini, SI Peña‐Corona… - Phytotherapy …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of amyloid‐beta plaques and neurofibrillary tangles, leading to neuronal loss …

[HTML][HTML] Anxiety adds the risk of cognitive progression and is associated with axon/synapse degeneration among cognitively unimpaired older adults

L Sun, W Li, Q Qiu, Y Hu, Z Yang, S Xiao - EBioMedicine, 2023 - thelancet.com
Background Mental symptoms have been shown to be associated with dementia. As the
most common neuropsychiatric disorder, it is unclear whether and why anxiety increases the …

An axis-referenced morphometric model reshaping the hippocampus following its longitudinal organization

N Gao, C Ye, H Chen, X Hao, T Ma - bioRxiv, 2023 - biorxiv.org
The anterior-posterior gradient of the human hippocampus on coronal slices is commonly
referred to as the long axis, which exhibits morphological heterogeneity related to aging and …