Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However,
only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD …

Diabetic nephropathy is a diabetic complication caused by chronic inflammation. As the
primary polyphenol in pomegranate, punicalagin is believed to have significant anti …

S-adenosylhomocysteine (SAH) is hydrolyzed by SAH hydrolase (SAHH) to homocysteine
and adenosine. Increased plasma SAH levels were associated with disturbed renal function …

Pyroptosis is one special type of lytic programmed cell death, featured in cell swelling,
rupture, secretion of cell contents and remarkable proinflammation effect. In the process of …

The development of new therapeutic approaches to diseases relies on the identification of
key molecular targets involved in amplifying disease processes. One such molecule is …

Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2
(TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which …

Background & Objective: Thioredoxin-interacting protein (TXNIP) also known as thioredoxin
binding protein-2 is a ubiquitously expressed protein that interacts and negatively regulates …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Activation of the
nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing …

We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at
specific loci over two different time points in people with diabetes are associated with …