Multimodal treatment strategies for patients with rectal cancer are increasingly including the
possibility of organ preservation, through nonoperative management or local excision …

Thirty per cent of all colorectal tumours develop in the rectum. The location of the rectum
within the bony pelvis and its proximity to vital structures presents significant therapeutic …

Background Radical surgery via total mesorectal excision might not be the optimal first-line
treatment for early-stage rectal cancer. An organ-preserving strategy with selective total …

Background GRECCAR 2 was the first multicentre, randomised trial to compare local
excision with total mesorectal excision in downstaged low rectal cancer. Encouraging …

Cancer cells can be conceived as “living organisms” interacting with cellular or non‐cellular
components in the host internal environment, not only the local tumor microenvironment but …

According to the main international clinical guidelines, the recommended treatment for
locally-advanced rectal cancer is neoadjuvant chemoradiotherapy followed by surgery …

Local recurrence after resection for rectal cancer remains common despite growing
acceptance that inadequate local excision may be implicated. In a prospective study of 190 …

Purpose This guideline reviews the evidence and provides recommendations for the
indications and appropriate technique and dose of neoadjuvant radiation therapy (RT) in the …

Aim Organ‐saving treatment for early‐stage rectal cancer can reduce patient‐reported side
effects compared to standard total mesorectal excision (TME) and preserve quality of life. An …

Background The risks of local recurrence and treatment-related morbidity need to be
balanced after local excision of early rectal cancer. The aim of this meta-analysis was to …