Oleoresin defenses in conifers: chemical diversity, terpene synthases and limitations of oleoresin defense under climate change

JM Celedon, J Bohlmann - New Phytologist, 2019 - Wiley Online Library
Conifers have evolved complex oleoresin terpene defenses against herbivores and
pathogens. In co‐evolved bark beetles, conifer terpenes also serve chemo‐ecological …

Engineering yeast for the production of plant terpenoids using synthetic biology approaches

JA Bureau, ME Oliva, Y Dong, C Ignea - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …

Metabolic engineering of Escherichia coli with electron channelling for the production of natural products

SY Park, H Eun, MH Lee, SY Lee - Nature Catalysis, 2022 - nature.com
The biosynthesis of natural products often requires eukaryotic cytochrome P450s (P450s) in
combination with P450 reductase, in physical proximity, to perform electron-transfer …

Microbial cell factories for the production of terpenoid flavor and fragrance compounds

FM Schempp, L Drummond, M Buchhaupt… - Journal of agricultural …, 2017 - ACS Publications
Terpenoid flavor and fragrance compounds are of high interest to the aroma industry.
Microbial production offers an alternative sustainable access to the desired terpenoids …

Identifying and engineering the ideal microbial terpenoid production host

S Moser, H Pichler - Applied Microbiology and Biotechnology, 2019 - Springer
More than 70,000 different terpenoid structures are known so far; many of them offer highly
interesting applications as pharmaceuticals, flavors and fragrances, or biofuels. Extraction of …

Coupling cell growth and biochemical pathway induction in Saccharomyces cerevisiae for production of (+)-valencene and its chemical conversion to (+)-nootkatone

Z Ye, Y Huang, B Shi, Z Xiang, Z Tian, M Huang… - Metabolic …, 2022 - Elsevier
Nootkatone is a valuable, functional sesquiterpene that is widely used in food, cosmetics,
pharmaceutical, agriculture, and other fields. However, only traces of it accumulate in plants …

Tailored carbon partitioning for phototrophic production of (E)-α-bisabolene from the green microalga Chlamydomonas reinhardtii

J Wichmann, T Baier, E Wentnagel, KJ Lauersen… - Metabolic …, 2018 - Elsevier
Photosynthetic microbial hosts such as cyanobacteria and eukaryotic microalgae have
recently emerged as alternative engineering platforms for the sustainable light-driven bio …

Production of the sesquiterpenoid (+)-nootkatone by metabolic engineering of Pichia pastoris

T Wriessnegger, P Augustin, M Engleder, E Leitner… - Metabolic …, 2014 - Elsevier
Abstract The sesquiterpenoid (+)-nootkatone is a highly demanded and highly valued aroma
compound naturally found in grapefruit, pummelo or Nootka cypress tree. Extraction of (+) …

Yarrowia lipolytica Strains Engineered for the Production of Terpenoids

JA Arnesen, KR Kildegaard… - … in Bioengineering and …, 2020 - frontiersin.org
Terpenoids are a diverse group of over 55,000 compounds with potential applications as
advanced fuels, bulk and fine chemicals, pharmaceutical ingredients, agricultural chemicals …

Making small molecules in plants: a chassis for synthetic biology‐based production of plant natural products

X Liu, P Zhang, Q Zhao… - Journal of Integrative Plant …, 2023 - Wiley Online Library
Plant natural products have been extensively exploited in food, medicine, flavor, cosmetic,
renewable fuel, and other industrial sectors. Synthetic biology has recently emerged as a …