To withstand the rigors of contraction, muscle fibers have specialized protein complexes that
buffer against mechanical stress and a multifaceted repair system that is rapidly activated …

This review discusses various issues to consider when developing standard operating
procedures for pre-clinical studies in the mdx mouse model of Duchenne muscular …

Duchenne muscular dystrophy (DMD) is an X-linked, degenerative muscle disease that is
exacerbated by secondary inflammation. Here, we characterized the immunological milieu …

Necrosis of skeletal muscle fibres in the lethal childhood myopathy Duchenne Muscular
Dystrophy results from deficiency of the cell membrane associated protein, dystrophin. We …

Mitochondrial stress may be a secondary contributor to muscle weakness in inherited
muscular dystrophies. Duchenne muscular dystrophy has received the majority of attention …

Duchenne muscular dystrophy (DMD) is a lethal X-linked musculodegenerative condition
consisting of an underlying genetic defect whose manifestation is augmented by …

Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease that affects boys and
leads to early death. In the quest for new treatments that improve the quality of life and in the …

Dystrophin deficiency results in lethal Duchenne muscular dystrophy (DMD). Substituting
missing dystrophin with abbreviated microdystrophin has dramatically alleviated disease in …

Muscular dystrophies primarily affect skeletal muscle. Mutations in a large number of genes,
mainly encoding cytoskeletal proteins, cause different forms of dystrophy that compromise …

The availability of animal models for Duchenne muscular dystrophy has led to extensive
preclinical research on potential therapeutics. Few studies have focused on reliability and …