Ins and outs of GPCR signaling in primary cilia
Primary cilia are specialized microtubule‐based signaling organelles that convey
extracellular signals into a cellular response in most vertebrate cell types. The physiological …
extracellular signals into a cellular response in most vertebrate cell types. The physiological …
Don't worry, be happy: endocannabinoids and cannabis at the intersection of stress and reward
ND Volkow, AJ Hampson… - Annual Review of …, 2017 - annualreviews.org
Cannabis enables and enhances the subjective sense of well-being by stimulating the
endocannabinoid system (ECS), which plays a key role in modulating the response to …
endocannabinoid system (ECS), which plays a key role in modulating the response to …
Multiple forms of endocannabinoid and endovanilloid signaling regulate the tonic control of GABA release
Persistent CB1 cannabinoid receptor activity limits neurotransmitter release at various
synapses throughout the brain. However, it is not fully understood how constitutively active …
synapses throughout the brain. However, it is not fully understood how constitutively active …
The cannabinoid receptor CB1 interacts with the WAVE1 complex and plays a role in actin dynamics and structural plasticity in neurons
The molecular composition of the cannabinoid type 1 (CB1) receptor complex beyond the
classical G-protein signaling components is not known. Using proteomics on mouse cortex …
classical G-protein signaling components is not known. Using proteomics on mouse cortex …
Protein interactors and trafficking pathways that regulate the cannabinoid type 1 receptor (CB1R)
A Fletcher-Jones, KL Hildick, AJ Evans… - Frontiers in molecular …, 2020 - frontiersin.org
The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress
synaptic transmission and plays a major role in a diverse range of brain functions including …
synaptic transmission and plays a major role in a diverse range of brain functions including …
Integrating endocannabinoid signaling in the regulation of anxiety and depression
A Yin, F Wang, X Zhang - Acta Pharmacologica Sinica, 2019 - nature.com
Brain endogenous cannabinoid (eCB) signaling seems to harmonize appropriate behavioral
responses, which are essential for the organism's long-term viability and homeostasis …
responses, which are essential for the organism's long-term viability and homeostasis …
Inhibiting Endocannabinoid hydrolysis as emerging analgesic strategy targeting a spectrum of ion channels implicated in migraine pain
A Della Pietra, J Savinainen, R Giniatullin - International Journal of …, 2022 - mdpi.com
Migraine is a disabling neurovascular disorder characterized by severe pain with still limited
efficient treatments. Endocannabinoids, the endogenous painkillers, emerged, alternative to …
efficient treatments. Endocannabinoids, the endogenous painkillers, emerged, alternative to …
The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression
A Fletcher-Jones, KL Hildick, AJ Evans, Y Nakamura… - Elife, 2019 - elifesciences.org
Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it
downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is …
downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is …
Visual-area-specific tonic modulation of GABA release by endocannabinoids sets the activity and coordination of neocortical principal neurons
F Koukouli, M Montmerle, A Aguirre, MDB Van Velze… - Cell Reports, 2022 - cell.com
Perisomatic inhibition of pyramidal neurons (PNs) coordinates cortical network activity
during sensory processing, and this role is mainly attributed to parvalbumin-expressing …
during sensory processing, and this role is mainly attributed to parvalbumin-expressing …
Cannabinoid receptors modulate neuronal morphology and AnkyrinG density at the axon initial segment
M Tapia, A Dominguez, W Zhang… - Frontiers in Cellular …, 2017 - frontiersin.org
Neuronal polarization underlies the ability of neurons to integrate and transmit information.
This process begins early in development with axon outgrowth, followed by dendritic growth …
This process begins early in development with axon outgrowth, followed by dendritic growth …