Circadian rhythms are natural rhythms that widely exist in all creatures, and regulate the
processes and physiological functions of various biochemical reactions. The circadian clock …

Colorectal cancer (CRC) is a dangerous form of cancer that affects the gastrointestinal tract.
It is a major global health concern, and the aggressive behavior of tumor cells makes it …

Epithelial–mesenchymal transition (EMT) is a transdifferentiation process wherein epithelial
cells acquire characteristics typical of mesenchymal cells. In this dynamic and reversible …

The circadian rhythm is generated at the cellular level by a molecular clock system that
involves specific genes. Studies have revealed that circadian clock disruption is a control …

The circadian clock is a timekeeping system for numerous biological rhythms that contribute
to the regulation of numerous homeostatic processes in humans. Disruption of circadian …

Platinum-based drugs (PBDs), including cisplatin, carboplatin, and oxaliplatin, have been
widely used as mainstay treatments for various types of cancer in clinical practice. Although …

In recent years, the incidences and mortalities from colorectal cancer (CRC) have been
increasing; therefore, there is an urgent need to discover newer drugs that enhance drug …

Circadian rhythms, including sleep/wake cycles as well as hormonal, immune, metabolic,
and cell proliferation rhythms, are fundamental biological processes driven by a cellular time …

Simple Summary Malignant tumors often escape therapy due to clonal propagation of a
subfraction of drug-resistant cancer cells. The underlying phenomenon of intratumoral …

Background Cancer metastasis is still a life threat to patients with colorectal cancer (CRC).
Brain and muscle ARNT‐like protein 1 (BMAL1) is an important biological proteins that can …