Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

In the adult brain, multiple cell types are known to produce factors that regulate blood–brain
barrier (BBB) properties, including astrocytes. Yet several recent studies disputed a role for …

Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting
delivery of blood flow to the brain. Hypertension also alters the blood-brain barrier (BBB), a …

Physical activity plays an essential role in maintaining a healthy body, yet it also provides
unique benefits for the vascular and cellular systems that sustain a healthy brain. While the …

Hypertension is a leading risk factor for dementia, but the mechanisms underlying its
damaging effects on the brain are poorly understood. Due to a lack of energy reserves, the …

The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Under conditions leading to aging and metabolic syndrome, the hypothalamus atypically
undergoes proinflammatory signaling activation leading to a chronic and stable background …

Angiotensin II (AngII) is implicated in neuroinflammation, blood-brain barrier (BBB)
disruption, and autonomic dysfunction in hypertension. We have previously shown that …