Rapid progress has been made in the understanding of the molecular interactions that result
in cell adhesion. Many adhesive proteins present in extracellular matrices and in the blood …

The platelet integrin αIIbβ3 is required for platelet aggregation. Like other integrins, αIIbβ3
resides on cell surfaces in an equilibrium between inactive and active conformations …

Lymphocyte function-associated antigen 1 (LFA-1) is a leukocyte cell surface giycopmtein
that promotes intelrceiiuiar adhesion in immunoiogicai and inflammatory reactions. it is an …

By David R. Phillips, Israel F. Charo, Leslie V. Parise, and Laurence A. Fitzgerald A NEW
FAMILY of cell-surface receptors has been identified that mediates a wide variety of cell-cell …

Integral membrane proteins are characterized by long apolar segments that cross the lipid
bilayer. Polar domains flanking these apolar segments have a more balanced amino acid …

Platelets have a key role in atherosclerosis, thrombosis, and acute coronary syndromes.
Therapeutic manipulation of platelet function has focused principally on the use of aspirin …

Starting 90 years ago with a clinical description by Glanzmann of a bleeding disorder
associated with a defect in platelet function, technologic advances helped investigators …

Introduction 3. Discussion 3.1. Fibronectin 3.2. Integrins 3.3. Molecular mechanisms of
ligand-integrin interactions 3.4. Ligand specificity of fibronectin binding integrins 3.5 …

Platelet aggregation is a critical event in thrombus formation and thus has extensive
involvement in physiological and pathological processes. The aggregation response …

We analyzed the binding of fibronectin to integrin alpha 5 beta 1 in various cells; in some
cells fibronectin bound with low affinity (eg, K562 cells) whereas in others (eg, CHO), it …