Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

Chromatin landscapes are disrupted during DNA replication and must be restored faithfully
to maintain genome regulation and cell identity. The histone H3-H4 modification landscape …

Transcription factors (TFs) interact with several other proteins in the process of
transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions for …

Prior studies suggested that SAGA and TFIID are alternative factors that promote RNA
polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA …

Acetyl-CoA is a key intermediate situated at the intersection of many metabolic pathways.
The reliance of histone acetylation on acetyl-CoA enables the coordination of gene …

Various factors differentially recognize trimethylated histone H3 lysine 4 (H3K4me3) near
promoters, H3K4me2 just downstream, and promoter-distal H3K4me1 to modulate gene …

Plants develop tolerance to drought by activating genes with altered levels of epigenetic
modifications. Specific transcription factors are involved in this activation, but the molecular …

Histones are highly covalently modified, but the functions of many of these modifications
remain unknown. In particular, it is unclear how histone marks are coupled to cellular …