Neuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is
both common and disabling, rendering an urgent need for non-addictive, effective new …

Personalised and targeted interventions have revolutionised cancer treatment and
dramatically improved survival rates in recent decades. Nonetheless, effective pain …

Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …

Aconitine (AC) is the primary bioactive and secondary metabolite alkaloidin of Aconitum
species which is accounted for more than 60% of the total diester-diterpenoid alkaloids in …

Pain is the most debilitating symptom of knee osteoarthritis (OA) that can even persist after
total knee replacement. The severity and duration of pain do not correlate well with joint …

The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into
six different categories and are collectively called the matrisome. The ECM plays pivotal …

The persistence of inflammatory and neuropathic pain is poorly understood. We investigated
a novel therapeutic paradigm by targeting gene networks that sustain or reverse persistent …

The dorsal root ganglia (DRG) are key structures in nociception and chronic pain disorders.
Several gene expression studies of DRG in preclinical pain models have been performed …

Neuropathic pain, characterized by persistent or intermittent spontaneous pain as well as
some unpleasant abnormal sensations, is one of the most prevalent health problems in the …

In this brief report, we demonstrate that the Cav3. 3 T-type voltage-gated calcium channel
subtype is involved in our FRICT-ION model of chronic trigeminal neuropathic pain. We first …