Since the early days of the intestinal microbiota research, mouse models have been used
frequently to study the interaction of microbes with their host. However, to translate the …

Chronic inflammation represents one of the most consistent biologic features of aging.
However, the precise etiology of persistent low-grade increases in inflammation remains …

Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …

Akkermansia muciniphila, an intestinal microorganism, belongs to Verrucomicrobia, one of
the most abundant microorganisms in the mammalian gut. It is a mucin-degrading bacterium …

Aging significantly increases the vulnerability to gastrointestinal (GI) disorders but there are
few studies investigating the key factors in aging that affect the GI tract. To address this …

Intestinal epithelial cells (IECs) serve as both a physical and an antimicrobial barrier against
the microbiota, as well as a conduit for signaling between the microbiota and systemic host …

Abstract Background The use of Akkermansia muciniphila as potential therapeutic
intervention is receiving increasing attention. Health benefits attributed to this bacterium …

The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical
barrier consisting of epithelial cells and immune cells, the latter residing underneath and …

The intestinal epithelial barrier protects the mucosa of the gastrointestinal (GI)-tract and
plays a key role in maintaining the host homeostasis. It encompasses several elements that …

Numerous bacteria are harbored in the animal digestive tract and are impacted by several
factors. Intestinal microbiota homeostasis is critical for maintaining the health of an …