In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

The chemical shift of a nucleus, i, in a molecule arises from the nuclear shielding effect of an
applied magnetic field, caused by an induced magnetic field resulting from circulation of …

α-Helical membrane proteins fulfill many vital roles in all living cells and constitute the
majority of drug targets. However, their relevance is in no way paralleled by our current …

We have used magnetic resonance to map the interaction surface of an integral membrane
protein for its regulatory target, an integral membrane enzyme. Phospholamban (PLN) …

The general approach for obtaining NMR constraints essential for determination of 3D
structure of proteins as well as its theoretical background were already discussed in Section …

The p24 proteins play an important role in the secretory pathway where they selectively
connect various cargo to other proteins, thereby being involved in the controlled assembly …

The sequence of phospholamban (PLB) is practically invariant among mammalian species.
The hydrophobic transmembrane domain has 10 leucine and 8 isoleucine residues. Two …

Phospholamban (PLB) is a membrane protein that regulates heart muscle relaxation rates
via interactions with the sarcoplasmic reticulum Ca2+ ATPase (SERCA). When PLB is …

For the first time, 15N solid‐state NMR experiments were conducted on wild‐type
phospholamban (WT‐PLB) embedded inside mechanically oriented phospholipid bilayers …