The discovery that the IL-23–IL-17 immune pathway is involved in many models of
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …

Low-grade inflammatory processes and related oxidative stress may have a key role in the
pathogenesis of hypertension and hypertension-mediated organ damage. Innate immune …

Objectives To assess the efficacy and safety of abatacept, a selective T-cell costimulation
modulator, in a phase III study in psoriatic arthritis (PsA). Methods This study randomised …

In recent years several studies investigated the role of T lymphocyte subpopulations in the
pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth …

The occurrence and development of rheumatoid arthritis (RA) is regulated by numerous
cytokines. Interleukin 27 (IL-27) is a soluble cytokine that exerts biological effects by …

Costimulatory interactions control T cell activation at sites of activated antigen-presenting
cells, including B cells. Blockade of the CD28/CD80/CD86 costimulatory axis with CTLA4Ig …

Gut microbiota and blood neutrophil-to-lymphocyte ratio (NLR) are associated with systemic
inflammation; however, data on the association between gut microbiota and NLR are …

Objective It has been previously demonstrated that T lymphocytes may be involved in the
development of hypertension and microvascular remodeling, and that circulating T effector …

The use of biological agents combined with methotrexate (MTX) in rheumatoid arthritis (RA)
patients has strongly improved disease outcome. In this study, the effects of abatacept on the …

T-helper (Th) 17.1 cells exhibit high pathogenicity in inflammatory diseases. This study
aimed to identify the changes in the proportions of Th subsets, including Th17. 1, which are …