Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes.
The main pathological changes were intestinal mucosal injury. Leucine-rich repeat …

Transforming growth factor β (TGF-β) is a ubiquitous molecule that is extremely conserved
structurally and plays a systemic role in human organism. TGF-β is a homodimeric molecule …

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, causing physical
impairments among the elderly. Core binding factor subunit β (Cbfβ) has a critical role in …

Given their worldwide distribution and toxicity to aquatic organisms, methylmercury (MeHg)
and microplastics (MP) are major pollutants in marine ecosystems. Although they commonly …

Yes-associated protein-1 (YAP-1) is a Hippo system transcription factor, which serves as an
oncogene in squamous cell carcinoma, and several solid tumors when the Hippo pathway is …

SP140, a lymphocytic-restricted protein, is an epigenetic reader working as a corepressor of
genes implicated in inflammation and orchestrating macrophage transcriptional programs to …

Melanoma is the most aggressive form of skin cancer. In the advanced stage of
development, it is resistant to currently available therapeutic modalities. Increased …

Extensive research has shown that PR domain 16 (PRDM16) plays a critical role in adipose
tissue metabolism, including processes such as browning and thermogenesis of adipocytes …

The prognosis for patients with non‑small cell lung cancer (NSCLC), a cancer type which
represents 85% of all lung cancers, is poor with a 5‑year survival rate of 19%, mainly …

In this review, we explore the intricate relationship between glucose metabolism and
mechanotransduction pathways, with a specific focus on the role of the Hippo signaling …