Applications of synthetic biology in medical and pharmaceutical fields

X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Synthetic cells in biomedical applications

W Sato, T Zajkowski, F Moser… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Synthetic cells are engineered vesicles that can mimic one or more salient features of life.
These features include directed localization, sense‐and‐respond behavior, gene …

Orthogonal light-activated DNA for patterned biocomputing within synthetic cells

D Hartmann, R Chowdhry, JM Smith… - Journal of the American …, 2023 - ACS Publications
Cell-free gene expression is a vital research tool to study biological systems in defined
minimal environments and has promising applications in biotechnology. Developing …

Cell-free gene expression: methods and applications

AC Hunt, BJ Rasor, K Seki, HM Ekas, KF Warfel… - Chemical …, 2024 - ACS Publications
Cell-free gene expression (CFE) systems empower synthetic biologists to build biological
molecules and processes outside of living intact cells. The foundational principle is that …

Light-regulated gene expression in Bacteria: Fundamentals, advances, and perspectives

R Ohlendorf, A Möglich - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Numerous photoreceptors and genetic circuits emerged over the past two decades and now
enable the light-dependent ie, optogenetic, regulation of gene expression in bacteria …

Engineering transmembrane signal transduction in synthetic membranes using two-component systems

JA Peruzzi, NR Galvez… - Proceedings of the …, 2023 - National Acad Sciences
Cells use signal transduction across their membranes to sense and respond to a wide array
of chemical and physical signals. Creating synthetic systems which can harness cellular …

Controlling synthetic cell-cell communication

JM Smith, R Chowdhry, MJ Booth - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Synthetic cells, which mimic cellular function within a minimal compartment, are finding wide
application, for instance in studying cellular communication and as delivery devices to living …

Advancing biomimetic functions of synthetic cells through compartmentalized cell-free protein synthesis

J Powers, Y Jang - Biomacromolecules, 2023 - ACS Publications
Synthetic cells are artificial constructs that mimic the structures and functions of living cells.
They are attractive for studying diverse biochemical processes and elucidating the origins of …

Precise, Orthogonal Remote-Control of Cell-Free Systems Using Photocaged Nucleic Acids

G Mazzotti, D Hartmann, MJ Booth - Journal of the American …, 2023 - ACS Publications
Cell-free expression of a gene to protein has become a vital tool in nanotechnology and
synthetic biology. Remote-control of cell-free systems with multiple, orthogonal wavelengths …

3D magnetic field-controlled synthesis, collective motion, and bioreaction enhancement of multifunctional peasecod-like nanochains

D Liu, S Li, T Zhang, H Jiang, Y Lu - ACS Applied Materials & …, 2021 - ACS Publications
Magnetic field-induced synthesis and biocatalysis of magnetic materials have inspired great
interest due to the flexible controllability of morphologies and unique magnetoelectrical …