A summary of the inaugural WHO classification of pediatric tumors: transitioning from the optical into the molecular era
SM Pfister, M Reyes-Múgica, JKC Chan, H Hasle… - Cancer discovery, 2022 - AACR
Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
ZFTA–RELA dictates oncogenic transcriptional programs to drive aggressive supratentorial ependymoma
A Arabzade, Y Zhao, S Varadharajan, HC Chen… - Cancer discovery, 2021 - AACR
More than 60% of supratentorial ependymomas harbor a ZFTA–RELA (ZRfus) gene fusion
(formerly C11orf95–RELA). To study the biology of ZRfus, we developed an autochthonous …
(formerly C11orf95–RELA). To study the biology of ZRfus, we developed an autochthonous …
The 2021 World Health Organization classification of tumors of the central nervous system: what neuroradiologists need to know
AG Osborn, DN Louis, TY Poussaint… - American Journal …, 2022 - Am Soc Neuroradiology
Neuroradiologists play a key role in brain tumor diagnosis and management. Staying current
with the latest classification systems and diagnostic markers is important to provide optimal …
with the latest classification systems and diagnostic markers is important to provide optimal …
The oncogenic fusion landscape in pediatric CNS neoplasms
Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-
related deaths in children. Recent developments in molecular analyses have greatly …
related deaths in children. Recent developments in molecular analyses have greatly …
Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion–positive supratentorial ependymomas
Molecular groups of supratentorial ependymomas comprise tumors with ZFTA–RELA or
YAP1-involving fusions and fusion-negative subependymoma. However, occasionally …
YAP1-involving fusions and fusion-negative subependymoma. However, occasionally …
Histone serotonylation regulates ependymoma tumorigenesis
Bidirectional communication between tumours and neurons has emerged as a key facet of
the tumour microenvironment that drives malignancy,. Another hallmark feature of cancer is …
the tumour microenvironment that drives malignancy,. Another hallmark feature of cancer is …
New insights into YAP/TAZ-TEAD-mediated gene regulation and biological processes in cancer
Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …
Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors
P Sievers, SC Henneken, C Blume, M Sill… - Acta …, 2021 - Springer
Ependymomas encompass a heterogeneous group of central nervous system (CNS)
neoplasms that occur along the entire neuroaxis. In recent years, extensive (epi-) genomic …
neoplasms that occur along the entire neuroaxis. In recent years, extensive (epi-) genomic …
TAZ/YAP fusion proteins: Mechanistic insights and therapeutic opportunities
The Hippo pathway is dysregulated in many different cancers, but point mutations in the
pathway are rare. Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes …
pathway are rare. Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes …