Unlike bacterial protein synthesis, eukaryotic protein synthesis has several mechanisms to
initiate translation including cap-dependent initiation, re-initiation and internal initiation …

Ribosome recruitment to eukaryotic mRNAs is generally thought to occur by a scanning
mechanism, whereby the 40S ribosomal subunit binds in the vicinity of the 5'cap structure of …

In multicellular organisms, gene regulatory circuits generate thousands of molecularly
distinct, mitotically heritable states through the property of multistability. Designing synthetic …

BACKGROUND Naturally occurring proteins sometimes have one or more domains, which
can serve different functions. Domains can target the protein to a certain nucleic acid …

Viruses are obligate intracellular parasites that depend on the host's protein synthesis
machinery for translating their mRNAs. The viral mRNA (vRNA) competes with the host …

We tested the hypothesis that induction of neuronal NO synthase (nNOS) impairs vascular
smooth muscle contractility after hypoxia. nNOS protein was increased in aorta, mesenteric …

Dengue virus (DENV) is an enveloped, positive-sense, single-stranded RNA virus belonging
to the Flaviviridae family. Translation initiation of DENV mRNA can occur by a cap …

Translation of some mRNAs is postulated to occur via an internal initiation mechanism which
is said to be augmented by a variety of RNA-binding proteins. A pervasive problem is that …

Picornaviruses and other positive-strand RNA viruses like hepatitis C virus (HCV) enter the
cell with a single RNA genome that directly serves as the template for translation …

Translation of most eukaryotic mRNAs involves the synergistic action between the 5′ cap
structure and the 3′ poly (A) tail at the initiation step. The poly (A) tail has also been shown …