The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Shal-type (Kv4. x) K+ channels are expressed in a variety of tissue, with particularly high
levels in the brain and heart. These channels are the primary subunits that contribute to …

Voltage-gated potassium (Kv) channels from the Kv4, or Shal-related, gene family underlie a
major component of the A-type potassium current in mammalian central neurons. We …

At least two functionally distinct transient outward K+ current (Ito) phenotypes can exist
across the free wall of the left ventricle (LV). Based upon their voltage‐dependent kinetics of …

The transient outward current (Ito), an important contributor to transmural
electrophysiological heterogeneity, is significantly remodelled in congestive heart failure …

Brain IA and cardiac I to currents arise from complexes containing Kv4 voltage-gated
potassium channels and cytoplasmic calcium-sensor proteins (KChIPs). Here, we present X …

Background—Potassium currents contribute to action potential duration (APD) and
arrhythmogenesis. In heart failure, Ca/calmodulin-dependent protein kinase II (CaMKII) is …

Kv4. 3 encodes the pore‐forming subunit of the cardiac transient outward potassium current
(I to). hKv4. 3‐encoded current does not fully replicate cardiac I to, suggesting a functionally …

A potentially important mechanism controlling ion channel expression is homeostatic
regulation, which can act to maintain a stable electrophysiological phenotype in cardiac …