Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the
main neuroendocrine secretory product of the pineal gland. Although melatonin is best …

Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Shift work that includes a nighttime rotation has become an unavoidable attribute of today's
24-h society. The related disruption of the human circadian time organization leads in the …

Context: Millions of individuals habitually expose themselves to room light in the hours
before bedtime, yet the effects of this behavior on melatonin signaling are not well …

Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological
and behavioral functions of almost all species. This pattern is due to a fundamental …

Based on the idea that electric light at night might account for a portion of the high and rising
risk of breast cancer worldwide, it was predicted long ago that women working a non-day …

The effect of CD on human health is an emerging issue. Many records link CD with diseases
such as cancer, cardiovascular, cognitive impairment and obesity, all of them conducive to …

It is commonly accepted that melatonin (N-acetyl-5-methoxytryptamine), the most relevant
pineal secretory product, has oncostatic properties in a wide variety of tumors and …

Most circadian rhythms are under the control of a major pacemaker located in the
hypothalamic suprachiasmatic nucleus. Some of these rhythms, called marker rhythms …