The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

The genome-wide architecture of chromatin-associated proteins that maintains chromosome
integrity and gene regulation is not well defined. Here we use chromatin …

Eukaryotic genomes are generally organized in multiple chromosomes. Here we have
created a functional single-chromosome yeast from a Saccharomyces cerevisiae haploid …

The budding yeast Saccharomyces cerevisiae is a powerful model organism for studying
fundamental aspects of eukaryotic cell biology. This Primer article presents a brief historical …

Although telomeres are heterochromatic, they are transcribed into noncoding telomeric
repeat–containing RNA (TERRA). Here we show that RNA-DNA hybrids form at telomeres …

Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

Telomerase is the essential reverse transcriptase required for linear chromosome
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …

Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin
structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard …

Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …