Lithium has been used for over half a century for the treatment of bipolar disorder as the
archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in …

The authors review existing structural and functional neuroimaging studies of patients with
bipolar disorder and discuss how these investigations enhance our understanding of the …

Objectives: The pathophysiology of sports-related concussion (SRC) is incompletely
understood. Human adult and experimental animal investigations have revealed structural …

Both major depressive disorder and bipolar disorder are the subject of a voluminous
imaging and genetics literature. Here, we attempt a comprehensive review of MRI and …

Current literature on the effects of chronic stress in general health converges to the concept
of allostatic load (AL). AL is the bodily 'wear and tear'that emerges with sustained allostatic …

Magnetic resonance spectroscopy (MRS) affords a noninvasive window on in vivo brain
chemistry and, as such, provides a unique opportunity to gain insight into the biochemical …

The measurement of brain metabolites with magnetic resonance spectroscopy (MRS)
provides a unique perspective on the brain bases of neuropsychiatric disorders. As a context …

Background Bipolar disorder (BD) has substantial morbidity and incompletely understood
neurobiological underpinnings. Objective To investigate brain chemistry in medication-free …

Bipolar disorder (BD) is a chronic psychiatric illness characterized by severe and biphasic
changes in mood. Several pathophysiological mechanisms have been hypothesized to …

White matter abnormalities constitute one element of the network dysfunction that underlies
affective disorders: differences between the white matter of subjects with affective disorders …