Mammalian prions are lethal transmissible pathogens that cause fatal neurodegenerative
diseases in humans and animals. They consist of fibrils of misfolded, host-encoded prion …

Today, the production and use of various samples of recombinant protein/polypeptide toxins
is known and is actively developing. This review presents state-of-the-art in research and …

Aβ plaques are one of the two lesions in the brain that define the neuropathological
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …

A common pathological denominator of various neurodegenerative diseases is the
accumulation of protein aggregates. Neurotoxic effects are caused by a loss of the …

In neurodegenerative diseases including Alzheimer's, Parkinson's and prion diseases,
astrocytes acquire disease-associated reactive phenotypes. With growing appreciation of …

Under normal conditions, astrocytes perform a number of important physiological functions
centered around neuronal support and synapse maintenance. In neurodegenerative …

Most cases of human prion disease arise due to spontaneous misfolding of WT or mutant
prion protein, yet recapitulating this event in animal models has proven challenging. It …

Abstract After Alzheimer's disease, Parkinson's disease is the most frequent
neurodegenerative disorder. Although numerous treatments have been developed to control …

Prion diseases are transmissible, neurodegenerative disorders associated with misfolding of
the prion protein. Previous studies show that reduction of microglia accelerates central …

Understanding why certain neurons are more sensitive to dysfunction and death caused by
misfolded proteins could provide therapeutically relevant insights into neurodegenerative …