Rodents are commonly used to study the pathophysiological mechanisms of pain as studies
in humans may be difficult to perform and ethically limited. As pain cannot be directly …

There is an art and science to performing mouse anesthesia, which is a significant
component to animal research. Frequently, anesthesia is one vital step of many over the …

Ensuring that laboratory rodent pain is well managed underpins the ethical acceptability of
working with these animals in research. Appropriate treatment of pain in laboratory rodents …

The minimization and alleviation of suffering has moral and scientific implications. In order to
mitigate this negative experience one must be able to identify when an animal is actually in …

With the advent of transgenic and other genetic engineering technologies, the versatility and
usefulness of the mouse as a model in biomedical research has soared. Revised to reflect …

Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively
extends the progression-free survival of breast, lung, and ovarian cancer patients. However …

Pain and its alleviation are currently a highly studied issue in human health. Research on
pain and response to analgesia has evolved to include the effects of genetics, heritability …

Dravet syndrome is a genetic encephalopathy characterized by severe epilepsy combined
with motor, cognitive, and behavioral abnormalities. Current antiepileptic drugs achieve only …

Recent studies have revealed some of the most frequently used analgesics in mice are not
effectively treating postoperative pain. Our laboratory sought to compare and assess the …

Pain-related functional impairment and behavioral depression are diagnostic indicators of
pain and targets for its treatment. Nesting is an innate behavior in mice that may be sensitive …