Nitric oxide (NO) is one of the most pleiotropic signaling molecules at systemic and cellular
levels, participating in vascular tone regulation, cellular respiration, proliferation, apoptosis …

BACKGROUND Emerging evidence from clinical and epidemiological studies suggests that
dietary polyphenols play an important role in the prevention of chronic diseases, including …

OBJECTIVE: The purpose of this study was to perform a comprehensive analysis of the
microRNA expression profile in placentas from preeclamptic pregnancies vs normal …

Preeclampsia, a multisystem hypertensive disorder of pregnancy, is associated with
increased systemic vascular resistance. Placentae from patients with preeclampsia have …

Estrogens, mainly 17β-estradiol (E2), play a critical role in reproductive organogenesis,
ovulation, and fertility via estrogen receptors. E2 is also a well-known regulator of utero …

Disruption of nitric oxide pathway and endoplasmic reticulum (ER) stress had been
observed in preeclampsia (PE). However, the correlation and overall detailed expression …

A well-functioning placenta is crucial for normal gestation and regulates the nutrient, gas,
and waste exchanges between the maternal and fetal circulations and is an important …

Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway and highly
expressed in the placenta. Deficiencies in HO-1, the inducible isoform, have been …

We postulate that an orchestrated network composed of various vasodilatory systems
participates in the systemic and local hemodynamic adaptations in pregnancy. The temporal …

Preeclampsia, a serious complication of pregnancy, involves intricate molecular and cellular
mechanisms. Fetal microchimerism, where fetal cells persist within maternal tissues and in …