The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …

The distinctive pathological hallmarks of Parkinson's disease are the progressive death of
dopaminergic neurons and the intracellular accumulation of Lewy bodies enriched in α …

The caspase family of cysteine proteases represents the executioners of programmed cell
death (PCD) type I or apoptosis. For years, caspases have been known for their critical roles …

Various species of non‐coding RNA s (ncRNAs) are enriched in specific subcellular
compartments, but the mechanisms orchestrating their localization and their local functions …

Tau, as a microtubule (MT)-associated protein, participates in key neuronal functions such
as the regulation of MT dynamics, axonal transport, and neurite outgrowth. Alternative …

Alterations in autophagy and the ubiquitin proteasome system (UPS) are commonly
implicated in protein aggregation and toxicity which manifest in a number of neurological …

Axons are processes of neurons, up to a metre long, that form the essential biological cables
wiring nervous systems. They must survive, often far away from their cell bodies and up to a …

Investigating the molecular mechanisms governing developmental axon growth has been a
useful approach for identifying new strategies for boosting axon regeneration after injury …

Dyrk1a triplication in Down's syndrome and its overexpression in Alzheimer's disease
suggest a role for increased DYRK1A activity in the abnormal metabolism of APP. Transport …

Protein degradation by the ubiquitin-proteasome system is critical for neuronal function.
Neurons utilize microtubule-dependent molecular motors to allocate proteasomes to …