Animal models of epilepsy: use and limitations

L Kandratavicius, PA Balista… - Neuropsychiatric …, 2014 - Taylor & Francis
Epilepsy is a chronic neurological condition characterized by recurrent seizures that affects
millions of people worldwide. Comprehension of the complex mechanisms underlying …

The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights

W Lazarini-Lopes, RA Do Val-da Silva… - Neuroscience & …, 2020 - Elsevier
Epilepsy is a neurological disorder characterized by the presence of seizures and
neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of …

[HTML][HTML] Animal models of epilepsy: a phenotype-oriented review

Y Wang, P Wei, F Yan, Y Luo, G Zhao - Aging and Disease, 2022 - ncbi.nlm.nih.gov
Epilepsy is a serious neurological disorder characterized by abnormal, recurrent, and
synchronous discharges in the brain. Long-term recurrent seizure attacks can cause serious …

Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system

TP Sutula, FE Dudek - Progress in brain research, 2007 - Elsevier
Seizure-induced sprouting of the mossy fiber pathway in the dentate gyrus has been
observed nearly universally in experimental models of limbic epilepsy and in the epileptic …

The Wistar Audiogenic Rat (WAR) strain and its contributions to epileptology and related comorbidities: history and perspectives

N Garcia-Cairasco, EHL Umeoka, JAC de Oliveira - Epilepsy & Behavior, 2017 - Elsevier
In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar
Audiogenic Rat (WAR), first introduced to the neuroscience international community more …

[HTML][HTML] Cortical excitability and neurology: insights into the pathophysiology

RAB Badawy, T Loetscher, RAL Macdonell… - Functional …, 2012 - ncbi.nlm.nih.gov
Transcranial magnetic stimulation (TMS) is a technique developed to non-invasively
investigate the integrity of human motor corticospinal tracts. Over the last three decades, the …

Dynamics of neurodegeneration in the hippocampus of Krushinsky-Molodkina rats correlates with the progression of limbic seizures

AA Kulikov, AA Naumova, NA Dorofeeva, AP Ivlev… - Epilepsy & Behavior, 2022 - Elsevier
Audiogenic seizures (AGS)(audiogenic kindling) in genetically selected audiogenic rodents
are a reliable model of temporal lobe epilepsy (TLE). Temporal lobe epilepsy is …

[HTML][HTML] Increased TRPV1 channels and FosB protein expression are associated with chronic epileptic seizures and Anxiogenic-like behaviors in a preclinical model …

W Lazarini-Lopes, GK Silva-Cardoso… - Biomedicines, 2022 - mdpi.com
Epilepsies are neurological disorders characterized by chronic seizures and their related
neuropsychiatric comorbidities, such as anxiety. The Transient Receptor Potential Vanilloid …

Inhibition of the renin–angiotensin system prevents seizures in a rat model of epilepsy

MGAG Pereira, C Becari, JAC Oliveira… - Clinical …, 2010 - portlandpress.com
The RAS (renin–angiotensin system) is classically involved in BP (blood pressure)
regulation and water–electrolyte balance, and in the central nervous system it has been …

[HTML][HTML] Study of spontaneous recurrent seizures and morphological alterations after status epilepticus induced by intrahippocampal injection of pilocarpine

MA Furtado, OW Castro, F Del Vecchio… - Epilepsy & Behavior, 2011 - Elsevier
Epileptic seizures are clinical manifestations of neuronal discharges characterized by
hyperexcitability and/or hypersynchrony in the cortex and other subcortical regions. The …