Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC)
with a poor prognosis. Current treatment options are limited to surgery, adjuvant …

Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …

Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a
supportive niche. Viewed through the lens of an ecosystem, numerous tumor components …

Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Metastasis has been considered as the terminal step of tumor progression. However, recent
genomic studies suggest that many metastases are initiated by further spread of other …

N 6-methyladenosine (m6A) modification of mRNA plays a role in regulating embryonic stem
cell pluripotency. However, the physiological signals that determine the balance between …

Abstract N6-methyladenosine (m6A) is the most abundant mRNA modification. With the
development of antibody-based sequencing technologies and the findings of m6A-related …

Radiotherapy (RT) is a modality of oncologic treatment that can be used to treat
approximately 50% of all cancer patients either alone or in combination with other treatment …

The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …