DNA is the central storage molecule of genetic information in the cell, and reading that
information is a central problem in biology. While sequencing technology has made …

Liposomes are structurally and functionally some of the most versatile supramolecular
assemblies in existence. Since the beginning of active research on lipid vesicles in 1965 …

This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

We have used a realistic model for double-stranded DNA and Monte Carlo simulations to
compute the extension (mean span) of a DNA molecule confined in a nanochannel over the …

The hyaluronan (HA) polymer is an important macromolecule of extracellular matrix with
remarkable structure and functions: it is a linear and unbranched polymer without sulphate …

Scaling regimes for polymers confined to tubular channels are well established when the
channel cross-sectional dimension is either very small (Odjik regime) or large (classic de …

Various efforts to integrate biological knowledge into networks of interactions have produced
a lively microbial systems biology. Putting molecular biology and computer sciences in …

DNA confinement in nanochannels is emerging as an important tool for genomics and an
excellent platform for testing the theories of confined wormlike polymers. Using cutting-edge …

Using pruned-enriched Rosenbluth method (PERM) simulations of a discrete wormlike
chain model, we provide compelling evidence in support of Odijk's prediction of two distinct …

We compare in detail the channel confinement of flexible and semiflexible chains over a
broad range of confinements and chain lengths using molecular simulations. Flexible and …